PKN1 and SPRR2D

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PKN1	SPRR2D
Description		protein kinase N1	small proline rich protein 2D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Cornified Envelope Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility	Epidermis Development Cornification
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Formation of the cornified envelope
Drugs
Diseases
GWAS		Urolithiasis ( 30975718)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282	2 interacting genes: MAPK6 PKN1
Entrez ID		5585	6703
HPRD ID		03019
Ensembl ID		ENSG00000123143	ENSG00000163216
Uniprot IDs		Q16512	P22532
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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