PKN1 and NEUROD2

Number of citations of the paper that reports this interaction (PubMedID 10640683)
5

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo, two hybrid)

		PKN1	NEUROD2
Description		protein kinase N1	neuronal differentiation 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Nuclear Chromatin Nucleus
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Heterodimerization Activity E-box Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility	Behavioral Fear Response Regulation Of Transcription By RNA Polymerase II Nervous System Development Associative Learning Protein Ubiquitination Cerebellar Cortex Development Positive Regulation Of Synaptic Plasticity Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Synapse Maturation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Synapse Maturation
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Urolithiasis ( 30975718)	Asthma ( 31619474) Mean corpuscular hemoglobin ( 27863252) Red blood cell count ( 27863252) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)
Interacting Genes		39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282	2 interacting genes: PKN1 TK1
Entrez ID		5585	4761
HPRD ID		03019	03429
Ensembl ID		ENSG00000123143	ENSG00000171532
Uniprot IDs		Q16512	Q15784
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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