RRN3 and EIF3L

Number of citations of the paper that reports this interaction (PubMedID 15004009)
156

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		RRN3	EIF3L
Description		RRN3 homolog, RNA polymerase I transcription factor	eukaryotic translation initiation factor 3 subunit L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Fibrillar Center Nucleoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Positive Regulation Of Neuron Projection Development Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	10 interacting genes: DNM2 EIF3D EIF3E EIF3K HRAS POLR1B RGS2 RRN3 SMAD2 XRN2
Entrez ID		54700	51386
HPRD ID		12004	10932
Ensembl ID		ENSG00000085721	ENSG00000100129
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	Q9Y262
PDB IDs			3J8B 3J8C 6FEC
Enriched GO Terms of Interacting Partners?
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