RRN3 and POLR1A

Number of citations of the paper that reports this interaction (PubMedID 11250903)
74

Data Source:
HPRD (in vivo, in vitro)

		RRN3	POLR1A
Description		RRN3 homolog, RNA polymerase I transcription factor	RNA polymerase I subunit A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleoplasm RNA Polymerase I Complex
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity	RNA Polymerase I Activity DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Positive Regulation Of Neuron Projection Development Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleolus
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)	Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	7 interacting genes: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4
Entrez ID		54700	25885
HPRD ID		12004	10161
Ensembl ID		ENSG00000085721	ENSG00000068654
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	O95602
PDB IDs
Enriched GO Terms of Interacting Partners?
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