RRN3 and PPP2R2A

Number of citations of the paper that reports this interaction (PubMedID 15004009)
156

Data Source:
BioGRID (pull down)

		RRN3	PPP2R2A
Description		RRN3 homolog, RNA polymerase I transcription factor	protein phosphatase 2 regulatory subunit Balpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol Glutamatergic Synapse
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity	Protein Binding Protein Phosphatase Regulator Activity Protein-containing Complex Binding Tau Protein Binding Protein Phosphatase 2A Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Positive Regulation Of Neuron Projection Development Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Dephosphorylation Mitotic Nuclear Envelope Reassembly Response To Morphine Regulation Of Phosphoprotein Phosphatase Activity Peptidyl-serine Dephosphorylation
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	Initiation of Nuclear Envelope (NE) Reformation Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 23563607) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	13 interacting genes: BRAF CHEK2 CREBBP GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1
Entrez ID		54700	5520
HPRD ID		12004	09223
Ensembl ID		ENSG00000085721	ENSG00000221914
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	A0A140VJT0 A0A590UJJ1 P63151
PDB IDs			3DW8
Enriched GO Terms of Interacting Partners?
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