EIF3L and RRN3

Number of citations of the paper that reports this interaction (PubMedID 15004009)
156

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		EIF3L	RRN3
Description		eukaryotic translation initiation factor 3 subunit L	RRN3 homolog, RNA polymerase I transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Polymerase I Core Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Positive Regulation Of Neuron Projection Development Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		10 interacting genes: DNM2 EIF3D EIF3E EIF3K HRAS POLR1B RGS2 RRN3 SMAD2 XRN2	10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		51386	54700
HPRD ID		10932	12004
Ensembl ID		ENSG00000100129	ENSG00000085721
Uniprot IDs		Q9Y262	B7ZB55 F5H148 Q9NYV6
PDB IDs		3J8B 3J8C 6FEC
Enriched GO Terms of Interacting Partners?
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