PLEKHA5 and PPP1R13B

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		PLEKHA5	PPP1R13B
Description		pleckstrin homology domain containing A5	protein phosphatase 1 regulatory subunit 13B
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	P53 Binding Protein Binding Transcription Factor Binding
	Biological Process	Biological_process Reproductive System Development	Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Synthesis of PIPs at the plasma membrane	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Thalamus volume ( 31530798)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)
Interacting Genes		36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	14 interacting genes: APC BRCA1 CCDC184 CDC5L CEP63 KHDRBS1 KHDRBS3 MIPOL1 PLEKHA5 PPP1CA TNIK TP63 TP73 TRAF1
Entrez ID		54477	23368
HPRD ID		09684	07345
Ensembl ID		ENSG00000052126	ENSG00000088808
Uniprot IDs		A0A024RAY7 Q9HAU0	Q96KQ4
PDB IDs		2DKP	6HL5
Enriched GO Terms of Interacting Partners?
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