PLEKHA5 and ARHGEF9

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		PLEKHA5	ARHGEF9
Description		pleckstrin homology domain containing A5	Cdc42 guanine nucleotide exchange factor 9
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Cytosol Postsynaptic Density Cell Junction
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Biological_process Reproductive System Development	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation GABA receptor activation
Drugs
Diseases			Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Thalamus volume ( 31530798)	Male-pattern baldness ( 28196072)
Interacting Genes		36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	7 interacting genes: BCL6 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TFIP11
Entrez ID		54477	23229
HPRD ID		09684	02337
Ensembl ID		ENSG00000052126	ENSG00000131089
Uniprot IDs		A0A024RAY7 Q9HAU0	B1AMR3 O43307
PDB IDs		2DKP	2YSQ
Enriched GO Terms of Interacting Partners?
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