RRM1 and BMI1

Number of citations of the paper that reports this interaction (PubMedID 24614341)
2

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RRM1	BMI1
Description		ribonucleotide reductase catalytic subunit M1	BMI1 proto-oncogene, polycomb ring finger
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Oxidation-reduction Process Retina Development In Camera-type Eye	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Segment Specification Regulation Of Gene Expression Hemopoiesis Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G0 To G1 Transition
Pathways		Interconversion of nucleotide di- and triphosphates	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon gallium maltolate
Diseases			Penile cancer
GWAS		Mean corpuscular hemoglobin ( 29403010) Red cell distribution width ( 27863252 28957414)	Prostate-specific antigen levels ( 28139693)
Interacting Genes		8 interacting genes: BMI1 LRIF1 NUP98 PPP1CC RNF2 RRM2 RRM2B YWHAG	37 interacting genes: CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 VPS11 ZBTB16
Entrez ID		6240	648
HPRD ID		01588	01277
Ensembl ID		ENSG00000167325	ENSG00000168283
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	P35226
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI	2H0D 2NA1 3RPG 4R8P 5FR6
Enriched GO Terms of Interacting Partners?
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