RRM1 and RRM2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		RRM1	RRM2
Description		ribonucleotide reductase catalytic subunit M1	ribonucleotide reductase regulatory subunit M2
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Oxidation-reduction Process Retina Development In Camera-type Eye	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Protein Heterotetramerization Oxidation-reduction Process Negative Regulation Of G0 To G1 Transition
Pathways		Interconversion of nucleotide di- and triphosphates	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon gallium maltolate	Cladribine Imexon Gallium nitrate motexafin gadolinium GTI 2040
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010) Red cell distribution width ( 27863252 28957414)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: BMI1 LRIF1 NUP98 PPP1CC RNF2 RRM2 RRM2B YWHAG	8 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B TP53
Entrez ID		6240	6241
HPRD ID		01588	01587
Ensembl ID		ENSG00000167325	ENSG00000171848
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	P31350
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI	2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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