RNF41 and LZTS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF41	LZTS2
Description		ring finger protein 41	leucine zipper tumor suppressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Centrosome Cytosol Microtubule Plasma Membrane Midbody Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Ral GTPase Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Proliferation Proteasomal Protein Catabolic Process Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Mitotic Cytokinesis Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474)	Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		39 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MNAT1 MTNR1A MTNR1B NEUROD4 ORMDL2 PPP1R1A RFC4 RNF166 RRM2B SUOX TBATA TRIM32 TRIM8 TSG101 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	176 interacting genes: ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARHGAP32 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C1orf109 C8orf33 CARD9 CBX8 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CEP57L1 CFAP206 CHCHD3 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DYRK2 EHHADH EIF3D EIF4E2 FAM107A FAM124B FAM161A FAM74A4 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 GATA1 GCC1 GEM GFI1B GLIDR GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 MAB21L3 MAGEB4 MEMO1 MORF4L1 MORF4L2 MORN3 MOS MTA1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAB2 PRPF31 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3RF2 SHFL SLC15A3 SLC25A6 SLU7 SMARCB1 SMIM3 SNHG11 SNW1 SNX31 SPATA2 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 TBC1D7 TCEA2 TCHP TEAD4 THAP10 THAP7 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TTC23 TXNL4A USF2 USP2 UTP14C WT1-AS YTHDC1 ZBTB25 ZBTB38 ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581
Entrez ID		10193	84445
HPRD ID		11520	14341
Ensembl ID		ENSG00000181852	ENSG00000107816
Uniprot IDs		A0A024RB33 Q9H4P4	B4DP66 Q9BRK4
PDB IDs		2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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