RNF41 and ORMDL2

		RNF41	ORMDL2
Description		ring finger protein 41	ORMDL sphingolipid biosynthesis regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Cell Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Ral GTPase Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Proliferation Proteasomal Protein Catabolic Process Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31619474)
Interacting Genes		39 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MNAT1 MTNR1A MTNR1B NEUROD4 ORMDL2 PPP1R1A RFC4 RNF166 RRM2B SUOX TBATA TRIM32 TRIM8 TSG101 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	2 interacting genes: DAPK1 RNF41
Entrez ID		10193	29095
HPRD ID		11520	17802
Ensembl ID		ENSG00000181852	ENSG00000123353
Uniprot IDs		A0A024RB33 Q9H4P4	Q53FV1
PDB IDs		2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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