TLE5 and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 11748221)
38

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TLE5	HMGB1
Description		TLE family member 5, transcriptional modulator	high mobility group box 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nuclear Chromatin Condensed Chromosome Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcriptional Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	Four-way Junction DNA Binding Bubble DNA Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Lyase Activity C-X-C Chemokine Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding RAGE Receptor Binding DNA Polymerase Binding Repressing Transcription Factor Binding Supercoiled DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Chromatin Silencing Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Signaling Receptor Activity Positive Regulation Of Autophagy Viral Process Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Developmental Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Chemotaxis DNA Ligation Involved In DNA Repair Positive Regulation Of DNA Ligation Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Neutrophil Clearance Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Vascular Endothelial Cell Proliferation Tumor Necrosis Factor Secretion Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Dendritic Cell Differentiation
Pathways		Repression of WNT target genes	Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Ethyl pyruvate
Diseases
GWAS			Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		165 interacting genes: ABI2 AEN AMH AR ARHGAP32 ATN1 ATP6V0D1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 CABP4 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CFAP206 CIB3 CPSF7 CRACR2A CRX DCUN1D1 DDX6 DGCR6 DIP2A DNMT3L DVL2 EAF1 EAF2 EIF4E2 FAM124A FAM124B FANCG FBF1 FBLN1 FHL3 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GLRX3 GOLGA2 GORASP2 GRAP2 GRB2 GTF2E1 HCN2 HGS HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPLL HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MIA2 MKRN3 MLH1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NLA NTAQ1 NUDT22 OLIG3 OSGIN1 PARVG PHKB POU2F1 PPP1R16A PPP1R16B PRDM1 PRKAA1 PRKAA2 PRKAB2 PRPF31 PRR3 PSMF1 PTRH2 QARS1 RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMARCB1 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 SUPT5H TBX3 TCF4 TMCC2 TNS2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBE2H UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576	94 interacting genes: ACBD3 AGER AGTRAP AR ATOH1 C1QBP C3 CASP3 CCAR1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DNM2 DNMT1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MECP2 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 SIX5 SOX18 SPINT1 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBE2I UNC119 ZFP36 ZNF24 ZNF428
Entrez ID		166	3146
HPRD ID		02556	01228
Ensembl ID		ENSG00000104964	ENSG00000189403
Uniprot IDs		Q08117 Q8WY48	A0A024RDR0 P09429
PDB IDs			2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM
Enriched GO Terms of Interacting Partners?
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