TLE5 and CALCOCO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TLE5	CALCOCO2
Description		TLE family member 5, transcriptional modulator	calcium binding and coiled-coil domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Factor Complex	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways		Repression of WNT target genes
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Chronotype ( 30696823) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		165 interacting genes: ABI2 AEN AMH AR ARHGAP32 ATN1 ATP6V0D1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 CABP4 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CFAP206 CIB3 CPSF7 CRACR2A CRX DCUN1D1 DDX6 DGCR6 DIP2A DNMT3L DVL2 EAF1 EAF2 EIF4E2 FAM124A FAM124B FANCG FBF1 FBLN1 FHL3 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GLRX3 GOLGA2 GORASP2 GRAP2 GRB2 GTF2E1 HCN2 HGS HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPLL HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MIA2 MKRN3 MLH1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NLA NTAQ1 NUDT22 OLIG3 OSGIN1 PARVG PHKB POU2F1 PPP1R16A PPP1R16B PRDM1 PRKAA1 PRKAA2 PRKAB2 PRPF31 PRR3 PSMF1 PTRH2 QARS1 RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMARCB1 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 SUPT5H TBX3 TCF4 TMCC2 TNS2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBE2H UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576	150 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FNDC11 FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HLX HNRNPLL HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TBC1D22B TBK1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TTC23L UBAC2 VARS1 VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF688
Entrez ID		166	10241
HPRD ID		02556	06846
Ensembl ID		ENSG00000104964	ENSG00000136436
Uniprot IDs		Q08117 Q8WY48	Q13137
PDB IDs			2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L
Enriched GO Terms of Interacting Partners?
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