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HSPA9 |
heat shock protein family A (Hsp70) member 9 |
- Mitochondrial protein import
- Regulation of HSF1-mediated heat shock response
- Cristae formation
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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IFI16 |
interferon gamma inducible protein 16 |
- STING mediated induction of host immune responses
- IRF3-mediated induction of type I IFN
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IKBKB |
inhibitor of nuclear factor kappa B kinase subunit beta |
- Activation of NF-kappaB in B cells
- Activation of NF-kappaB in B cells
- ER-Phagosome pathway
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- Downstream TCR signaling
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- IKBKB deficiency causes SCID
- IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
- IkBA variant leads to EDA-ID
- CLEC7A (Dectin-1) signaling
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
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- Mesalazine
- Sulfasalazine
- Acetylsalicylic acid
- Auranofin
- Arsenic trioxide
- MLN0415
- Acetylcysteine
- Ertiprotafib
- Fostamatinib
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ING1 |
inhibitor of growth family member 1 |
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ING4 |
inhibitor of growth family member 4 |
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ING5 |
inhibitor of growth family member 5 |
- HATs acetylate histones
- Regulation of TP53 Activity through Acetylation
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IRF7 |
interferon regulatory factor 7 |
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Interferon gamma signaling
- TICAM1-dependent activation of IRF3/IRF7
- Interferon alpha/beta signaling
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
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ITPK1 |
inositol-tetrakisphosphate 1-kinase |
- Synthesis of pyrophosphates in the cytosol
- Synthesis of IP3 and IP4 in the cytosol
- Factors involved in megakaryocyte development and platelet production
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JDP2 |
Jun dimerization protein 2 |
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JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated MAPK activation
- Activation of the AP-1 family of transcription factors
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- WNT5:FZD7-mediated leishmania damping
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- Adapalene
- Vinblastine
- Pseudoephedrine
- Irbesartan
- Arsenic trioxide
- LGD-1550
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KAT2A |
lysine acetyltransferase 2A |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HATs acetylate histones
- Notch-HLH transcription pathway
- B-WICH complex positively regulates rRNA expression
- Ub-specific processing proteases
- RNA Polymerase I Transcription Initiation
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
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KAT2B |
lysine acetyltransferase 2B |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HATs acetylate histones
- Notch-HLH transcription pathway
- B-WICH complex positively regulates rRNA expression
- Physiological factors
- Metalloprotease DUBs
- RNA Polymerase I Transcription Initiation
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
- Estrogen-dependent gene expression
- Regulation of FOXO transcriptional activity by acetylation
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- Coenzyme A
- (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
- N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
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KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
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- Coenzyme A
- S-Acetyl-Cysteine
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KAT6A |
lysine acetyltransferase 6A |
- HATs acetylate histones
- Regulation of TP53 Activity through Acetylation
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KAT7 |
lysine acetyltransferase 7 |
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KAT8 |
lysine acetyltransferase 8 |
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KDM1A |
lysine demethylase 1A |
- HDACs deacetylate histones
- HDMs demethylate histones
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- Potential therapeutics for SARS
- Factors involved in megakaryocyte development and platelet production
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KDM4D |
lysine demethylase 4D |
- HDMs demethylate histones
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KIAA0087 |
KIAA0087 lncRNA |
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KLF4 |
Kruppel like factor 4 |
- Transcriptional regulation of white adipocyte differentiation
- Synthesis, secretion, and deacylation of Ghrelin
- Transcriptional regulation of pluripotent stem cells
- FOXO-mediated transcription of cell cycle genes
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