|
CRK |
CRK proto-oncogene, adaptor protein |
- ARMS-mediated activation
- ARMS-mediated activation
- Downstream signal transduction
- Regulation of actin dynamics for phagocytic cup formation
- p130Cas linkage to MAPK signaling for integrins
- VEGFA-VEGFR2 Pathway
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
- MET activates RAP1 and RAC1
- MET receptor recycling
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
|
|
|
|
EIF2S2 |
eukaryotic translation initiation factor 2 subunit beta |
- L13a-mediated translational silencing of Ceruloplasmin expression
- PERK regulates gene expression
- PERK regulates gene expression
- ABC-family proteins mediated transport
- Translation initiation complex formation
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Recycling of eIF2:GDP
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
|
|
|
|
KPNB1 |
karyopherin subunit beta 1 |
- ISG15 antiviral mechanism
- Apoptosis induced DNA fragmentation
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Transport of Ribonucleoproteins into the Host Nucleus
- NS1 Mediated Effects on Host Pathways
- Nuclear import of Rev protein
- Nuclear import of Rev protein
- Initiation of Nuclear Envelope (NE) Reformation
- Neutrophil degranulation
- Postmitotic nuclear pore complex (NPC) reformation
- Inhibition of nitric oxide production
|
|
|
|
PPARGC1A |
PPARG coactivator 1 alpha |
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- SUMOylation of transcription cofactors
- Circadian Clock
- Circadian Clock
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
|
|
|
|
PPP1CC |
protein phosphatase 1 catalytic subunit gamma |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Triglyceride catabolism
- Downregulation of TGF-beta receptor signaling
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Circadian Clock
- RHO GTPases Activate Formins
- RAF activation
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
- Signaling by MRAS-complex mutants
|
- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- Motuporin
|
|
|
PRKAB2 |
protein kinase AMP-activated non-catalytic subunit beta 2 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Macroautophagy
- AMPK inhibits chREBP transcriptional activation activity
- AMPK inhibits chREBP transcriptional activation activity
- Carnitine metabolism
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of TP53 Activity through Phosphorylation
- Lipophagy
- Activation of AMPK downstream of NMDARs
|
- Adenosine phosphate
- Acetylsalicylic acid
- Fostamatinib
|
|
|
RUNX3 |
RUNX family transcription factor 3 |
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates NOTCH signaling
- Regulation of RUNX3 expression and activity
- RUNX3 Regulates Immune Response and Cell Migration
- RUNX3 Regulates Immune Response and Cell Migration
- RUNX3 regulates WNT signaling
- RUNX3 regulates YAP1-mediated transcription
- RUNX3 regulates RUNX1-mediated transcription
- RUNX3 regulates p14-ARF
- RUNX3 regulates BCL2L11 (BIM) transcription
|
|
|
|
ARAF |
A-Raf proto-oncogene, serine/threonine kinase |
- RAF activation
- MAP2K and MAPK activation
- Negative regulation of MAPK pathway
- Signaling by moderate kinase activity BRAF mutants
- Signaling by high-kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
- Signaling by MRAS-complex mutants
|
|
- Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
|
|
ATR |
ATR serine/threonine kinase |
- Meiotic synapsis
- Activation of ATR in response to replication stress
- Regulation of HSF1-mediated heat shock response
- HDR through Single Strand Annealing (SSA)
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Fanconi Anemia Pathway
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
|
|
- Alveolar rhabdomyosarcoma
- Seckel syndrome
|
|
CHEK1 |
checkpoint kinase 1 |
- Signaling by SCF-KIT
- Activation of ATR in response to replication stress
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Transcriptional Regulation by E2F6
|
- XL844
- Enzastaurin
- CHIR-124
- N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
- 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
- (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
- 2-(cyclohexylamino)benzoic acid
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
- (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
- 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
- (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
- 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
- (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
- 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
- 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
- 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
- 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
- (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
- (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
- N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
- (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
- 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
- 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
- 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
- 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
- REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
- 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
- N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
- 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
- [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
- 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
- 6-MORPHOLIN-4-YL-9H-PURINE
- 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
- Fostamatinib
|
|
|
CSNK1D |
casein kinase 1 delta |
- COPII-mediated vesicle transport
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Circadian Clock
- Anchoring of the basal body to the plasma membrane
- Major pathway of rRNA processing in the nucleolus and cytosol
- AURKA Activation by TPX2
|
|
|
|
CSNK2B |
casein kinase 2 beta |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Neutrophil degranulation
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
|
|
|
|
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated MAPK activation
- Activation of the AP-1 family of transcription factors
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- Estrogen-dependent gene expression
- NGF-stimulated transcription
- NGF-stimulated transcription
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
|
- Pseudoephedrine
- Nadroparin
|
|
|
HIF1A |
hypoxia inducible factor 1 subunit alpha |
- Regulation of gene expression by Hypoxia-inducible Factor
- Cellular response to hypoxia
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- NOTCH1 Intracellular Domain Regulates Transcription
- Circadian Clock
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- PTK6 Expression
- PTK6 promotes HIF1A stabilization
- Neddylation
|
- Carvedilol
- Hydralazine
- 2-Methoxyestradiol
- ENMD-1198
- PX-478
- FG-2216
|
|
|
RING1 |
ring finger protein 1 |
- Oxidative Stress Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription cofactors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA methylation proteins
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Transcriptional Regulation by E2F6
|
|
|
|
SIN3A |
SIN3 transcription regulator family member A |
- SUMOylation of transcription cofactors
- Regulation of lipid metabolism by PPARalpha
- NoRC negatively regulates rRNA expression
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Loss of MECP2 binding ability to 5mC-DNA
- Regulation of MECP2 expression and activity
- MECP2 regulates neuronal receptors and channels
- MECP2 regulates transcription of neuronal ligands
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Factors involved in megakaryocyte development and platelet production
|
|
|
|
TAF9B |
TATA-box binding protein associated factor 9b |
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- Ub-specific processing proteases
- RNA Polymerase II Pre-transcription Events
- Regulation of TP53 Activity through Phosphorylation
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
|
|
|
|
TXN |
thioredoxin |
- Oxidative Stress Induced Senescence
- Detoxification of Reactive Oxygen Species
- Interconversion of nucleotide di- and triphosphates
- TP53 Regulates Metabolic Genes
- Protein repair
- The NLRP3 inflammasome
- The NLRP3 inflammasome
- Regulation of FOXO transcriptional activity by acetylation
- Purinergic signaling in leishmaniasis infection
- Purinergic signaling in leishmaniasis infection
|
|
|
|
UBE2D3 |
ubiquitin conjugating enzyme E2 D3 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- TICAM1, RIP1-mediated IKK complex recruitment
- Signaling by BMP
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
CDK5 |
cyclin dependent kinase 5 |
- DARPP-32 events
- CRMPs in Sema3A signaling
- CRMPs in Sema3A signaling
- Regulation of TP53 Activity through Phosphorylation
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- NGF-stimulated transcription
- Activated NTRK2 signals through CDK5
- Factors involved in megakaryocyte development and platelet production
|
- Indirubin-3'-monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Alvocidib
- Alsterpaullone
- 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
|
|