SRC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
ADAM15	ADAM metallopeptidase domain 15	Degradation of the extracellular matrix Invadopodia formation
AFAP1	actin filament associated protein 1
AFAP1L2	actin filament associated protein 1 like 2
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANKRD11	ankyrin repeat domain 11
ANXA7	annexin A7
ARHGAP1	Rho GTPase activating protein 1	Rho GTPase cycle
ARHGAP17	Rho GTPase activating protein 17	Rho GTPase cycle
ARHGAP32	Rho GTPase activating protein 32	Rho GTPase cycle
ARHGAP35	Rho GTPase activating protein 35	Rho GTPase cycle Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
ARR3	arrestin 3
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
ATG9A	autophagy related 9A	Macroautophagy
BCAR1	BCAR1 scaffold protein, Cas family member	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
BCCIP	BRCA2 and CDKN1A interacting protein
CAV1	caveolin 1	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes	Congenital generalized lipodystrophy (CGL)
CAV2	caveolin 2	Extra-nuclear estrogen signaling
CBL	Cbl proto-oncogene	Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL Regulation of signaling by CBL Negative regulation of FLT3 FLT3 signaling by CBL mutants	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
CBLC	Cbl proto-oncogene C
CCDC180	coiled-coil domain containing 180

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