SRC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
MICAL1	microtubule associated monooxygenase, calponin and LIM domain containing 1	Factors involved in megakaryocyte development and platelet production
MPZL1	myelin protein zero like 1
NANS	N-acetylneuraminate synthase	Sialic acid metabolism
NCOA6	nuclear receptor coactivator 6	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis
NEDD4	NEDD4 E3 ubiquitin protein ligase	ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
NPHS1	NPHS1 adhesion molecule, nephrin	Nephrin family interactions Nephrin family interactions	Nephrotic syndrome and focal segmental glomerulosclerosis
PDCD6IP	programmed cell death 6 interacting protein	Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
PECAM1	platelet and endothelial cell adhesion molecule 1	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis	Lethal congenital contractural syndrome (LCCS)
PKD1	polycystin 1, transient receptor potential channel interacting	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Polycystic kidney disease
PLCG1	phospholipase C gamma 1	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
PLSCR1	phospholipid scramblase 1
PRKCH	protein kinase C eta	Effects of PIP2 hydrolysis G alpha (z) signalling events
PROM1	prominin 1		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
PTPA	protein phosphatase 2 phosphatase activator
PTPN18	protein tyrosine phosphatase non-receptor type 18	Downregulation of ERBB2 signaling Interleukin-37 signaling
PTPN2	protein tyrosine phosphatase non-receptor type 2	Negative regulation of MET activity Interleukin-37 signaling	Type I diabetes mellitus
PTPN21	protein tyrosine phosphatase non-receptor type 21
PTPRA	protein tyrosine phosphatase receptor type A	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade

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