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FOXO1 |
forkhead box O1 |
- AKT phosphorylates targets in the nucleus
- Regulation of gene expression in beta cells
- AKT-mediated inactivation of FOXO1A
- Constitutive Signaling by AKT1 E17K in Cancer
- MAPK6/MAPK4 signaling
- Interleukin-4 and Interleukin-13 signaling
- Regulation of localization of FOXO transcription factors
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Regulation of FOXO transcriptional activity by acetylation
- Regulation of FOXO transcriptional activity by acetylation
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
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- Alveolar rhabdomyosarcoma
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FRS2 |
fibroblast growth factor receptor substrate 2 |
- PI3K Cascade
- PIP3 activates AKT signaling
- Frs2-mediated activation
- Frs2-mediated activation
- Constitutive Signaling by Aberrant PI3K in Cancer
- PI-3K cascade:FGFR1
- FRS-mediated FGFR1 signaling
- PI-3K cascade:FGFR2
- FRS-mediated FGFR2 signaling
- FRS-mediated FGFR3 signaling
- PI-3K cascade:FGFR3
- FRS-mediated FGFR4 signaling
- PI-3K cascade:FGFR4
- Negative regulation of FGFR1 signaling
- Negative regulation of FGFR2 signaling
- Negative regulation of FGFR3 signaling
- Negative regulation of FGFR4 signaling
- Signaling by FGFR2 in disease
- Signaling by FGFR4 in disease
- Signaling by FGFR1 in disease
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Signaling by FGFR3 fusions in cancer
- Signaling by FGFR3 point mutants in cancer
- RET signaling
- Activated NTRK2 signals through FRS2 and FRS3
- Activated NTRK2 signals through FRS2 and FRS3
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FYB1 |
FYN binding protein 1 |
- Generation of second messenger molecules
- Generation of second messenger molecules
- Signal regulatory protein family interactions
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FZR1 |
fizzy and cell division cycle 20 related 1 |
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- Phosphorylation of Emi1
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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GAB1 |
GRB2 associated binding protein 1 |
- PI3K Cascade
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- PIP3 activates AKT signaling
- GAB1 signalosome
- PI3K events in ERBB2 signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Constitutive Signaling by EGFRvIII
- PI-3K cascade:FGFR1
- PI-3K cascade:FGFR2
- PI-3K cascade:FGFR3
- PI-3K cascade:FGFR4
- Signaling by FGFR2 in disease
- Signaling by FGFR4 in disease
- Signaling by FGFR1 in disease
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- MET activates PI3K/AKT signaling
- Signaling by FGFR3 fusions in cancer
- Signaling by FGFR3 point mutants in cancer
- RET signaling
- MET activates PTPN11
- MET activates RAP1 and RAC1
- MET receptor recycling
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Activated NTRK2 signals through PI3K
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
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GAB2 |
GRB2 associated binding protein 2 |
- PI3K Cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- Signaling by cytosolic FGFR1 fusion mutants
- Constitutive Signaling by Aberrant PI3K in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- RET signaling
- Interleukin-15 signaling
- Interleukin receptor SHC signaling
- FLT3 Signaling
- FLT3 Signaling
- STAT5 Activation
- STAT5 activation downstream of FLT3 ITD mutants
- Signaling by FLT3 fusion proteins
- Signaling by FLT3 fusion proteins
- Signaling by FLT3 ITD and TKD mutants
- Signaling by FLT3 ITD and TKD mutants
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GAB3 |
GRB2 associated binding protein 3 |
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GALNT12 |
polypeptide N-acetylgalactosaminyltransferase 12 |
- Defective GALNT12 causes colorectal cancer 1 (CRCS1)
- O-linked glycosylation of mucins
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GFAP |
glial fibrillary acidic protein |
- Nuclear signaling by ERBB4
- Chaperone Mediated Autophagy
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GIT1 |
GIT ArfGAP 1 |
- Ephrin signaling
- Ephrin signaling
- Activation of RAC1 downstream of NMDARs
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GJB1 |
gap junction protein beta 1 |
- Oligomerization of connexins into connexons
- Oligomerization of connexins into connexons
- Transport of connexins along the secretory pathway
- Gap junction assembly
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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GRB10 |
growth factor receptor bound protein 10 |
- Signaling by SCF-KIT
- IRS activation
- Signal attenuation
- Insulin receptor signalling cascade
- RET signaling
- FLT3 Signaling
- Response of EIF2AK1 (HRI) to heme deficiency
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GTF2I |
general transcription factor IIi |
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HEMGN |
hemogen |
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INPPL1 |
inositol polyphosphate phosphatase like 1 |
- Synthesis of PIPs at the plasma membrane
- Synthesis of IP3 and IP4 in the cytosol
- Interleukin receptor SHC signaling
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KHDRBS1 |
KH RNA binding domain containing, signal transduction associated 1 |
- PTK6 Regulates Proteins Involved in RNA Processing
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KIFAP3 |
kinesin associated protein 3 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- MHC class II antigen presentation
- Intraflagellar transport
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
- Kinesins
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MAPK8IP3 |
mitogen-activated protein kinase 8 interacting protein 3 |
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MAPRE1 |
microtubule associated protein RP/EB family member 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
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MED28 |
mediator complex subunit 28 |
- PPARA activates gene expression
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
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