ESR1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
DHX9	DExH-box helicase 9	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway
EPRS1	glutamyl-prolyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol	Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
FKBP5	FKBP prolyl isomerase 5	HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling MECP2 regulates neuronal receptors and channels
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Copper Artenimol
HNRNPC	heterogeneous nuclear ribonucleoprotein C	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
JUND	JunD proto-oncogene, AP-1 transcription factor subunit	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
KARS1	lysyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	L-Lysine	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
MED21	mediator complex subunit 21	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
MPG	N-methylpurine DNA glycosylase	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1	Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
NPPA	natriuretic peptide A	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation		Atrial fibrillation
RACK1	receptor for activated C kinase 1	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production	Copper
RANBP9	RAN binding protein 9	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
SARNP	SAP domain containing ribonucleoprotein	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
TAP1	transporter 1, ATP binding cassette subfamily B member	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC		Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
TNFRSF14	TNF receptor superfamily member 14	Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors
TRIM24	tripartite motif containing 24	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
TRIM28	tripartite motif containing 28	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
ACTN4	actinin alpha 4	Platelet degranulation Nephrin family interactions		Nephrotic syndrome and focal segmental glomerulosclerosis
ARID1A	AT-rich interaction domain 1A	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

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