CTNNB1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
FHL2	four and a half LIM domains 2	PPARA activates gene expression
FOXO1	forkhead box O1	AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	Alveolar rhabdomyosarcoma
FOXO4	forkhead box O4	AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
FSCN1	fascin actin-bundling protein 1	Interleukin-4 and Interleukin-13 signaling
FUS	FUS RNA binding protein	mRNA Splicing - Major Pathway	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GLIS2	GLIS family zinc finger 2		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GNA13	G protein subunit alpha 13	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
H1-2	H1.2 linker histone, cluster member	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
IGF2BP1	insulin like growth factor 2 mRNA binding protein 1	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MAPK6/MAPK4 signaling
JADE1	jade family PHD finger 1	HATs acetylate histones
KMT2A	lysine methyltransferase 2A	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
KMT2D	lysine methyltransferase 2D	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Kabuki syndrome
LATS2	large tumor suppressor kinase 2	Signaling by Hippo
LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	Nephrin family interactions
MEN1	menin 1	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation	Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma
MITF	melanocyte inducing transcription factor	SUMOylation of transcription factors	Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS) Malignant melanoma
NDRG1	N-myc downstream regulated 1	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy

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