CTNNB1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
NEURL2	neuralized E3 ubiquitin protein ligase 2	Neddylation
NF2	neurofibromin 2	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
NOTCH1	notch receptor 1	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
PECAM1	platelet and endothelial cell adhesion molecule 1	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
PICK1	protein interacting with PRKCA 1	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
PITX2	paired like homeodomain 2	TFAP2 (AP-2) family regulates transcription of other transcription factors	Axenfeld-Rieger syndrome (ARS)
PKD1	polycystin 1, transient receptor potential channel interacting	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Polycystic kidney disease
PKP2	plakophilin 2	Keratinization Formation of the cornified envelope	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent 1A	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
PSEN1	presenilin 1	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3	Acne inversa; Hidradenitis supprativa Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Alzheimer's disease (AD)
PSEN2	presenilin 2	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3	Alzheimer's disease (AD)
PTPN13	protein tyrosine phosphatase non-receptor type 13	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
PTPN14	protein tyrosine phosphatase non-receptor type 14	Interleukin-37 signaling	Choanal atresia and lymphedema
PTPRF	protein tyrosine phosphatase receptor type F	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
PTPRJ	protein tyrosine phosphatase receptor type J	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
PTPRK	protein tyrosine phosphatase receptor type K	EGFR downregulation
PTPRM	protein tyrosine phosphatase receptor type M
PTPRU	protein tyrosine phosphatase receptor type U	Signaling by SCF-KIT
PTPRZ1	protein tyrosine phosphatase receptor type Z1	Other interleukin signaling
PYGO1	pygopus family PHD finger 1	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex

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