CTNNB1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
BCL9L	BCL9 like	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
BOC	BOC cell adhesion associated, oncogene regulated	Ligand-receptor interactions Activation of SMO
CA9	carbonic anhydrase 9	Regulation of gene expression by Hypoxia-inducible Factor Reversible hydration of carbon dioxide	Benzthiazide Benzthiazide Cyclothiazide Hydroflumethiazide Zonisamide Girentuximab Ellagic acid Sodium carbonate
CDH5	cadherin 5	Adherens junctions interactions VEGFR2 mediated vascular permeability	Lenalidomide FX06
DSC3	desmocollin 3	Keratinization Formation of the cornified envelope		Hypotrichosis and recurrent skin vesicles
ELAVL1	ELAV like RNA binding protein 1	HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
FLT1	fms related receptor tyrosine kinase 1	Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib
GRIK2	glutamate ionotropic receptor kainate type subunit 2	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
H1-2	H1.2 linker histone, cluster member	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
IGF2BP1	insulin like growth factor 2 mRNA binding protein 1	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MAPK6/MAPK4 signaling
NF2	neurofibromin 2	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs		Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
PICK1	protein interacting with PRKCA 1	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
PKD1	polycystin 1, transient receptor potential channel interacting	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium		Polycystic kidney disease
PKP2	plakophilin 2	Keratinization Formation of the cornified envelope		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent 1A	Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK
PTPN13	protein tyrosine phosphatase non-receptor type 13	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
PTPRF	protein tyrosine phosphatase receptor type F	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
PYGO1	pygopus family PHD finger 1	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
RUVBL2	RuvB like AAA ATPase 2	Telomere Extension By Telomerase HATs acetylate histones	Quercetin

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