ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
RCN1	reticulocalbin 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
RNF31	ring finger protein 31	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
RNF4	ring finger protein 4	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
SLC6A13	solute carrier family 6 member 13	Na+/Cl- dependent neurotransmitter transporters Reuptake of GABA	Guvacine
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SREBF1	sterol regulatory element binding transcription factor 1	RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
ST6GALNAC6	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	Sialic acid metabolism Lewis blood group biosynthesis
TOLLIP	toll interacting protein	Neutrophil degranulation Interleukin-1 signaling
TRIM32	tripartite motif containing 32	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation		Bardet-Biedl syndrome (BBS)
UBE2E3	ubiquitin conjugating enzyme E2 E3	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
ACOT7	acyl-CoA thioesterase 7	Mitochondrial Fatty Acid Beta-Oxidation
ADD3	adducin 3	Miscellaneous transport and binding events
ANP32A	acidic nuclear phosphoprotein 32 family member A	HuR (ELAVL1) binds and stabilizes mRNA
APBB1	amyloid beta precursor protein binding family B member 1	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
ARHGAP32	Rho GTPase activating protein 32	Rho GTPase cycle
ATF5	activating transcription factor 5	Response of EIF2AK1 (HRI) to heme deficiency	Pseudoephedrine
BHLHE40	basic helix-loop-helix family member e40	BMAL1:CLOCK,NPAS2 activates circadian gene expression
CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Choline Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
CLCN2	chloride voltage-gated channel 2	Stimuli-sensing channels	Lubiprostone Cobiprostone	Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
CRY2	cryptochrome circadian regulator 2	Circadian Clock

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