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MLST8 |
MTOR associated protein, LST8 homolog |
- PIP3 activates AKT signaling
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- HSF1-dependent transactivation
- Energy dependent regulation of mTOR by LKB1-AMPK
- CD28 dependent PI3K/Akt signaling
- VEGFR2 mediated vascular permeability
- TP53 Regulates Metabolic Genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of TP53 Degradation
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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YWHAZ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Deactivation of the beta-catenin transactivating complex
- Rap1 signalling
- GP1b-IX-V activation signalling
- KSRP (KHSRP) binds and destabilizes mRNA
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Negative regulation of NOTCH4 signaling
- Regulation of localization of FOXO transcription factors
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HSPA1A |
heat shock protein family A (Hsp70) member 1A |
- Viral RNP Complexes in the Host Cell Nucleus
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Neutrophil degranulation
- Regulation of HSF1-mediated heat shock response
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Attenuation phase
- HSF1-dependent transactivation
- Neutrophil degranulation
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CRK |
CRK proto-oncogene, adaptor protein |
- ARMS-mediated activation
- ARMS-mediated activation
- Downstream signal transduction
- Regulation of actin dynamics for phagocytic cup formation
- p130Cas linkage to MAPK signaling for integrins
- VEGFA-VEGFR2 Pathway
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
- MET activates RAP1 and RAC1
- MET receptor recycling
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
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DCTN3 |
dynactin subunit 3 |
- MHC class II antigen presentation
- Regulation of PLK1 Activity at G2/M Transition
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- COPI-mediated anterograde transport
- COPI-independent Golgi-to-ER retrograde traffic
- AURKA Activation by TPX2
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CCNK |
cyclin K |
- Formation of RNA Pol II elongation complex
- Formation of HIV elongation complex in the absence of HIV Tat
- HIV elongation arrest and recovery
- Pausing and recovery of HIV elongation
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- RNA Polymerase II Pre-transcription Events
- TP53 Regulates Transcription of DNA Repair Genes
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase II Transcription Elongation
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PIAS1 |
protein inhibitor of activated STAT 1 |
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- Formation of Incision Complex in GG-NER
- Regulation of IFNG signaling
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CDK6 |
cyclin dependent kinase 6 |
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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- Alvocidib
- (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol
- Fisetin
- Palbociclib
- Ribociclib
- Abemaciclib
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NCAM1 |
neural cell adhesion molecule 1 |
- ECM proteoglycans
- NCAM signaling for neurite out-growth
- NCAM signaling for neurite out-growth
- NCAM1 interactions
- NCAM1 interactions
- Signal transduction by L1
- RAF/MAP kinase cascade
- Interferon gamma signaling
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USP7 |
ubiquitin specific peptidase 7 |
- Ub-specific processing proteases
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Regulation of TP53 Degradation
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Regulation of PTEN localization
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NFYA |
nuclear transcription factor Y subunit alpha |
- PPARA activates gene expression
- Activation of gene expression by SREBF (SREBP)
- Activation of gene expression by SREBF (SREBP)
- ATF4 activates genes in response to endoplasmic reticulum stress
- ATF6 (ATF6-alpha) activates chaperone genes
- ATF6 (ATF6-alpha) activates chaperone genes
- FOXO-mediated transcription of cell death genes
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PML |
PML nuclear body scaffold |
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of ubiquitinylation proteins
- Regulation of TP53 Activity through Acetylation
- Interferon gamma signaling
- Regulation of RUNX1 Expression and Activity
- Regulation of PTEN localization
- HCMV Early Events
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- Acute myeloid leukemia (AML)
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RAPGEF1 |
Rap guanine nucleotide exchange factor 1 |
- Frs2-mediated activation
- Frs2-mediated activation
- Downstream signal transduction
- MET activates RAP1 and RAC1
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
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SREBF2 |
sterol regulatory element binding transcription factor 2 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- PPARA activates gene expression
- Activation of gene expression by SREBF (SREBP)
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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STAM2 |
signal transducing adaptor molecule 2 |
- EGFR downregulation
- Ub-specific processing proteases
- Negative regulation of MET activity
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- InlB-mediated entry of Listeria monocytogenes into host cell
- Endosomal Sorting Complex Required For Transport (ESCRT)
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ACACA |
acetyl-CoA carboxylase alpha |
- ChREBP activates metabolic gene expression
- Biotin transport and metabolism
- Carnitine metabolism
- Activation of gene expression by SREBF (SREBP)
- Defective HLCS causes multiple carboxylase deficiency
- Fatty acyl-CoA biosynthesis
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ATP6V0D1 |
ATPase H+ transporting V0 subunit d1 |
- ROS and RNS production in phagocytes
- XBP1(S) activates chaperone genes
- Insulin receptor recycling
- Transferrin endocytosis and recycling
- Amino acids regulate mTORC1
- Ion channel transport
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CFL1 |
cofilin 1 |
- Platelet degranulation
- Regulation of actin dynamics for phagocytic cup formation
- EPHB-mediated forward signaling
- Sema3A PAK dependent Axon repulsion
- RHO GTPases Activate ROCKs
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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- Dodecyldimethylamine N-oxide
- Copper
- Artenimol
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EIF3F |
eukaryotic translation initiation factor 3 subunit F |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
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ESRRA |
estrogen related receptor alpha |
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Transcriptional activation of mitochondrial biogenesis
- Nuclear Receptor transcription pathway
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
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- Troglitazone
- Diethylstilbestrol
- Genistein
- Afimoxifene
- beta-Naphthoflavone
- 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
- Flavone
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