ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
LPAR2	lysophosphatidic acid receptor 2	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
PICALM	phosphatidylinositol binding clathrin assembly protein	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
TOMM20	translocase of outer mitochondrial membrane 20	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
ADAM15	ADAM metallopeptidase domain 15	Degradation of the extracellular matrix Invadopodia formation
DHX37	DEAH-box helicase 37	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
EFEMP2	EGF containing fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EPN2	epsin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF fusions FGFR2 alternative splicing
FDPS	farnesyl diphosphate synthase	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate
FOSL1	FOS like 1, AP-1 transcription factor subunit	NGF-stimulated transcription NGF-stimulated transcription
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	Glycolysis Gluconeogenesis	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
GGA2	golgi associated, gamma adaptin ear containing, ARF binding protein 2	TBC/RABGAPs Amyloid fiber formation
IST1	IST1 factor associated with ESCRT-III	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
KAT6A	lysine acetyltransferase 6A	HATs acetylate histones Regulation of TP53 Activity through Acetylation
KCNAB2	potassium voltage-gated channel subfamily A regulatory beta subunit 2	Voltage gated Potassium channels Neutrophil degranulation	Enflurane Promethazine Miconazole
KMT2B	lysine methyltransferase 2B	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
LDB1	LIM domain binding 1	RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
LOXL1	lysyl oxidase like 1	Elastic fibre formation Crosslinking of collagen fibrils
PTGDS	prostaglandin D2 synthase	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation	Vitamin A

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