ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ouabain	Primary torsion dystonia (PTD)
ATP6V0D1	ATPase H+ transporting V0 subunit d1	ROS and RNS production in phagocytes XBP1(S) activates chaperone genes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Tiludronic acid
ATXN1L	ataxin 1 like
ATXN2	ataxin 2			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
ATXN2L	ataxin 2 like
BAALC	BAALC binder of MAP3K1 and KLF4
BASP1	brain abundant membrane attached signal protein 1
BATF2	basic leucine zipper ATF-like transcription factor 2
BEND2	BEN domain containing 2
BHLHE40	basic helix-loop-helix family member e40	BMAL1:CLOCK,NPAS2 activates circadian gene expression
BICRAL	BRD4 interacting chromatin remodeling complex associated protein like
BTG3	BTG anti-proliferation factor 3
C10orf55	chromosome 10 putative open reading frame 55
C1orf94	chromosome 1 open reading frame 94
CAMK1	calcium/calmodulin dependent protein kinase I	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs	Fostamatinib
CAMK2B	calcium/calmodulin dependent protein kinase II beta	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
CCDC136	coiled-coil domain containing 136
CCNK	cyclin K	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
CDIP1	cell death inducing p53 target 1
CDK6	cyclin dependent kinase 6	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Alvocidib (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol Fisetin Palbociclib Ribociclib Abemaciclib

Search Results for: ATXN1