PPP4R1 and SASH1

Data Source:
BioGRID (two hybrid)

		PPP4R1	SASH1
Description		protein phosphatase 4 regulatory subunit 1	SAM and SH3 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Protein Serine/threonine Phosphatase Complex Protein Phosphatase 4 Complex	Cytoplasm Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Lean body mass ( 28552196) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)	Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		5 interacting genes: CEP63 DISC1 HDAC3 PPP4C SASH1	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		9989	23328
HPRD ID		05366	06408
Ensembl ID		ENSG00000154845	ENSG00000111961
Uniprot IDs		Q8TF05	O94885
PDB IDs			2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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