SASH1 and EPS8L2

Data Source:
BioGRID (two hybrid)

		SASH1	EPS8L2
Description		SAM and SH3 domain containing 1	EPS8 like 2
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GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Cytosol Plasma Membrane Vesicle Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	9 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2 TRIM55 TRIM63
Entrez ID		23328	64787
HPRD ID		06408	10940
Ensembl ID		ENSG00000111961	ENSG00000177106
Uniprot IDs		O94885	Q9H6S3
PDB IDs		2DL0 2EBP	1WWU 1WXB
Enriched GO Terms of Interacting Partners?
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