KLK4 and SERPINA3

Data Source:
HPRD (in vitro)

		KLK4	SERPINA3
Description		kallikrein related peptidase 4	serpin family A member 3
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GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Amelogenesis	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways			Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Amelogenesis imperfecta
GWAS		Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		3 interacting genes: SERPINA3 SHBG TYRO3	27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		9622	12
HPRD ID		04793	00120
Ensembl ID		ENSG00000167749	ENSG00000196136
Uniprot IDs		A0A0C4DFQ5 Q5BQA0 Q96PT1 Q9Y5K2	A0A024R6P0 P01011
PDB IDs		2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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