KLK4 and TYRO3

Data Source:
BioGRID (two hybrid)

		KLK4	TYRO3
Description		kallikrein related peptidase 4	TYRO3 protein tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Metal Ion Binding	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Amelogenesis	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle
Pathways
Drugs			Fostamatinib
Diseases		Amelogenesis imperfecta
GWAS		Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		3 interacting genes: SERPINA3 SHBG TYRO3	28 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 GRB2 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1
Entrez ID		9622	7301
HPRD ID		04793	02641
Ensembl ID		ENSG00000167749	ENSG00000092445
Uniprot IDs		A0A0C4DFQ5 Q5BQA0 Q96PT1 Q9Y5K2	H0YNK6 Q06418
PDB IDs		2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21	1RHF
Enriched GO Terms of Interacting Partners?
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