BCAR1 and AJUBA

Data Source:
HPRD (two hybrid, in vivo)

		BCAR1	AJUBA
Description		BCAR1 scaffold protein, Cas family member	ajuba LIM protein
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon	P-body Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Lamellipodium
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Alpha-catenin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription, DNA-templated Cytoskeleton Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Kinase Activity Cellular Protein Localization Gene Silencing By MiRNA Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Regulation Of GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia Positive Regulation Of Gene Silencing By MiRNA
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of PLK1 Activity at G2/M Transition Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insular cortex volume ( 31530798) Macular thickness ( 30535121) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Spatial processing ( 31596458)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	20 interacting genes: ACTA1 AURKAIP1 AURKB BCAR1 CATSPER1 CREB5 CTNNA1 FARS2 GFI1B GRB2 LATS2 LCK LGALS14 PIN1 SLC1A2 TEKT3 TFAP4 TSG101 ZNF512B ZNF541
Entrez ID		9564	84962
HPRD ID		04248	16426
Ensembl ID		ENSG00000050820	ENSG00000129474
Uniprot IDs		B3KWE2 P56945	Q96IF1
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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