BCAR1 and ANKS1A

Data Source:
BioGRID (two hybrid)

		BCAR1	ANKS1A
Description		BCAR1 scaffold protein, Cas family member	ankyrin repeat and sterile alpha motif domain containing 1A
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon	Nucleoplasm Cytosol Neuron Projection
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Protein Binding Ephrin Receptor Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization	Substrate-dependent Cell Migration Neuron Remodeling Ephrin Receptor Signaling Pathway Regulation Of Ephrin Receptor Signaling Pathway
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 28552196 23563607 18391951) Mean platelet volume ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	99 interacting genes: ABI2 ADGRL1 ALDOC ANKRD55 ARAP3 ARHGAP10 BCAR1 BLZF1 C17orf50 C19orf54 C22orf39 C3orf36 C9orf152 CADPS CCDC184 CCDC33 CHCHD3 CYSRT1 DAB2IP DOK3 EGFR ERBB2 ERBB4 ESM1 FAM217B FAM221A FAM86C1P FCHSD2 FHL5 GOLGA2 GPRIN2 HOXA1 HOXC8 ID3 IKZF3 ISCA2 ITIH6 KCTD9 KEAP1 KIAA1328 KLF15 KLHL26 KPRP KRT31 KRT34 KRT39 KRT75 KRT83 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP19-7 KRTAP4-2 KRTAP6-2 KRTAP9-3 LASP1 LHX2 LNX1 MBD3L1 MED20 MEOX2 MID2 MTUS2 NADSYN1 NBPF19 NEDD9 NHLRC2 NOTCH2NLA NUTM2F PIK3R3 PRDM6 PRKAR1B RANBP3 RB1 RIN1 RNF144B RORB RUSC1 SCN5A SH3KBP1 SHISA6 SLC15A2 SMARCD1 SORBS3 SPATA12 SPRED1 TOX2 TP53BP1 TRIM29 TRIT1 UBC USP54 USP7 YWHAG ZBTB32 ZBTB42 ZC2HC1C ZNF135
Entrez ID		9564	23294
HPRD ID		04248	10610
Ensembl ID		ENSG00000050820	ENSG00000064999
Uniprot IDs		B3KWE2 P56945	Q05CP0 Q92625
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q	2LMR 2MYQ 6F7O
Enriched GO Terms of Interacting Partners?
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