BCAR1 and PLPP3

Data Source:
HPRD (in vitro)

		BCAR1	PLPP3
Description		BCAR1 scaffold protein, Cas family member	phospholipid phosphatase 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Basolateral Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Integrin Binding Protein Binding Phosphatidate Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization	Negative Regulation Of Protein Phosphorylation Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Sphingolipid Biosynthetic Process Cell-cell Adhesion Mediated By Integrin Homotypic Cell-cell Adhesion Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Endothelial Cell Migration Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cell-cell Adhesion Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Wound Healing Phospholipid Dephosphorylation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	Coronary artery disease ( 30104761 33020668) Heel bone mineral density ( 30598549) Low density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	4 interacting genes: APP BCAR1 CTNND1 SHC1
Entrez ID		9564	8613
HPRD ID		04248	06179
Ensembl ID		ENSG00000050820	ENSG00000162407
Uniprot IDs		B3KWE2 P56945	O14495
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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