AJUBA and GFI1B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AJUBA	GFI1B
Description		ajuba LIM protein	growth factor independent 1B transcriptional repressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Lamellipodium	Nucleus Nucleoplasm Transcription Regulator Complex Plasma Membrane Nuclear Matrix
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Alpha-catenin Binding Metal Ion Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription, DNA-templated Cytoskeleton Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Kinase Activity Cellular Protein Localization Gene Silencing By MiRNA Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Regulation Of GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia Positive Regulation Of Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of PLK1 Activity at G2/M Transition Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Insular cortex volume ( 31530798) Macular thickness ( 30535121) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Spatial processing ( 31596458)	Basophil percentage of white cells ( 27863252) Cardiometabolic and hematological traits ( 27668658) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		20 interacting genes: ACTA1 AURKAIP1 AURKB BCAR1 CATSPER1 CREB5 CTNNA1 FARS2 GFI1B GRB2 LATS2 LCK LGALS14 PIN1 SLC1A2 TEKT3 TFAP4 TSG101 ZNF512B ZNF541	71 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 POLR1H PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRF3
Entrez ID		84962	8328
HPRD ID		16426	05088
Ensembl ID		ENSG00000129474	ENSG00000165702
Uniprot IDs		Q96IF1	A0A024R8F3 Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?
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