NCOR2 and AHR

Data Source:
HPRD (in vivo)

		NCOR2	AHR
Description		nuclear receptor corepressor 2	aryl hydrocarbon receptor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Aryl Hydrocarbon Receptor Complex Cytosolic Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Regulation Of Lipid Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression CAMP-mediated Signaling Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs			Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-monoxime Resveratrol Quercetin beta-Naphthoflavone Emodin 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Diosmin Indigotindisulfonic acid Kynurenic Acid Epigallocatechin gallate Cantharidin Indirubin
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood metabolite levels ( 24816252) Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption ( 31345160 21357676 31959922 29367735 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 26192919) Lung cancer in ever smokers ( 28604730) Metabolic traits ( 21886157) Microalbuminuria ( 31511532) Plasma kynurenine levels in major depressive disorder ( 29317604) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Sweet beverage consumption ( 31046077) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Ulcerative colitis ( 26192919) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		89 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A	35 interacting genes: AIP AR ARNT ARNT2 ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		9612	196
HPRD ID		02910	02596
Ensembl ID		ENSG00000196498	ENSG00000106546
Uniprot IDs		C9J0Q5 C9JE98 Q9Y618	A0A024R9Z8 P35869
PDB IDs		1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ	5NJ8
Enriched GO Terms of Interacting Partners?
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