FXR2 and LCMT1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		FXR2	LCMT1
Description		FMR1 autosomal homolog 2	leucine carboxyl methyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Presynapse Dendritic Filopodium	Nucleoplasm Cytosol
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Protein C-terminal Carboxyl O-methyltransferase Activity Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Protein C-terminal Leucine Carboxyl O-methyltransferase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Positive Regulation Of Response To DNA Damage Stimulus	G2/M Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Protein Methylation C-terminal Protein Methylation Regulation Of Glucose Metabolic Process Negative Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Cyclin A/B1/B2 associated events during G2/M transition
Drugs			Leucine
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Cleft palate ( 28054174) Lead levels ( 26025379)
Interacting Genes		107 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARL6IP1 BAZ2B BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CBS CCDC33 CCDC85B CCR4 CDKL3 CEP44 CEP55 COIL CWF19L2 CYFIP1 CYFIP2 DDX17 DMRTB1 DPPA2 DYNLT1 EIF4G1 EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GKAP1 GTSE1 HMBOX1 HNRNPC IGFN1 INPP5J KCNRG KCTD4 KIAA1217 KIF1A KIF2A KRT20 KXD1 LASP1 LCMT1 LCP2 LDOC1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MRPL43 NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NME1 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PIM1 POM121 PRAM1 PRC1 PSME3 PTS RABAC1 RALYL RBBP8 RBM14 RBMX RBPMS RPIA RTN3 RTN4 SCEL SNAP23 SYT6 SYTL4 TBC1D22B THAP1 TNNT1 TRAF2 TRIM23 TRIM29 TRIM37 TSC22D4 YES1 ZBTB22 ZBTB8A ZMAT2 ZNF232 ZNF451 ZNRD2 ZSCAN1	4 interacting genes: BRCA1 FXR2 PPP2CB TAB1
Entrez ID		9513	51451
HPRD ID		05629	17266
Ensembl ID		ENSG00000129245	ENSG00000205629
Uniprot IDs		P51116	Q9UIC8
PDB IDs		3H8Z	3IEI 3O7W 3P71
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?