AKAP5 and TRPV1

Data Source:
BioGRID (pull down, pull down)

		AKAP5	TRPV1
Description		A-kinase anchoring protein 5	transient receptor potential cation channel subfamily V member 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Dendrite Membrane Dendritic Spine Membrane Raft Excitatory Synapse Postsynaptic Recycling Endosome	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Dendritic Spine Membrane Postsynaptic Membrane
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding	Transmembrane Signaling Receptor Activity Ion Channel Activity Extracellular Ligand-gated Ion Channel Activity Excitatory Extracellular Ligand-gated Ion Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Phosphatidylinositol Binding Metal Ion Binding Phosphoprotein Binding
	Biological Process	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport	Cell Surface Receptor Signaling Pathway Chemosensory Behavior Cellular Response To Heat Thermoception Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Alkaloid Cellular Response To ATP Cellular Response To Acidic PH Calcium Ion Import Across Plasma Membrane Response To Capsazepine
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	TRP channels
Drugs			alpha-Linolenic acid Icosapent Aspartame Tramadol Acetaminophen Camphor Ricinoleic Acid Resiniferatoxin Capsaicin Cannabidiol Zucapsaicin Propacetamol Capsicum oleoresin Nonivamide (S)-camphor Medical Cannabis Nabiximols Cannabidivarin
Diseases
GWAS
Interacting Genes		21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1	8 interacting genes: AKAP5 CALM1 EGFR ITCH PRKCE SNAPIN SYT9 TRPV2
Entrez ID		9495	7442
HPRD ID		05255	03648
Ensembl ID		ENSG00000179841	ENSG00000196689
Uniprot IDs		P24588 Q6PG46	Q8NER1
PDB IDs		2H9R 3LL8 5NIN	6L93
Enriched GO Terms of Interacting Partners?
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