AKAP5 and GABRB3

Data Source:
HPRD (in vitro, in vivo)

		AKAP5	GABRB3
Description		A-kinase anchoring protein 5	gamma-aminobutyric acid type A receptor subunit beta3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Dendrite Membrane Dendritic Spine Membrane Raft Excitatory Synapse Postsynaptic Recycling Endosome	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding	GABA-A Receptor Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Identical Protein Binding
	Biological Process	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Roof Of Mouth Development Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Piperazine Ivermectin Medroxyprogesterone acetate Clorazepic acid Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Muscimol Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS			Body mass index ( 28892062) Cognitive performance ( 19734545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 20834067) Pericalcarine cortex volume ( 31530798) Postprandial triglyceride response ( 32603185) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1	8 interacting genes: AKAP5 ARFGEF2 MEOX2 PPP2CA PRKACA PRKCA RACK1 UBQLN1
Entrez ID		9495	2562
HPRD ID		05255	08844
Ensembl ID		ENSG00000179841	ENSG00000166206
Uniprot IDs		P24588 Q6PG46	B2RCW8 P28472 X5DQY4
PDB IDs		2H9R 3LL8 5NIN	4COF 5O8F 5OJM 6A96 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53
Enriched GO Terms of Interacting Partners?
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