SLC22A2 and KRTCAP2

Data Source:
BioGRID (protein complementation assay)

		SLC22A2	KRTCAP2
Description		solute carrier family 22 member 2	keratinocyte associated protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Presynapse	Oligosaccharyltransferase Complex Integral Component Of Membrane
	Molecular Function	Amine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	Enzyme Activator Activity
	Biological Process	Neurotransmitter Transport Drug Transmembrane Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotransmitter Secretion Body Fluid Secretion Positive Regulation Of Gene Expression Organic Cation Transport Amine Transport Choline Transport Neurotransmitter Biosynthetic Process Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-alpha-amino Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier	Protein N-linked Glycosylation Protein N-linked Glycosylation Via Arginine Regulation Of Catalytic Activity
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Waist circumference ( 26785701)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dentures ( 31235808) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 30804560) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Peak expiratory flow ( 30804560) Perceived intensity of sucrose ( 31005972) PR interval ( 30046033 32439900) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 EXT2 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1	5 interacting genes: APP CREB3 SHD SLC22A1 SLC22A2
Entrez ID		6582	200185
HPRD ID		04008	17253
Ensembl ID		ENSG00000112499	ENSG00000163463
Uniprot IDs		O15244	Q8N6L1
PDB IDs
Enriched GO Terms of Interacting Partners?
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