SLC22A2 and CLPTM1

Data Source:
BioGRID (protein complementation assay)

		SLC22A2	CLPTM1
Description		solute carrier family 22 member 2	CLPTM1 regulator of GABA type A receptor forward trafficking
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Presynapse	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane
	Molecular Function	Amine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	Protein Binding
	Biological Process	Neurotransmitter Transport Drug Transmembrane Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotransmitter Secretion Body Fluid Secretion Positive Regulation Of Gene Expression Organic Cation Transport Amine Transport Choline Transport Neurotransmitter Biosynthetic Process Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-alpha-amino Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier	Multicellular Organism Development Cell Differentiation Regulation Of T Cell Differentiation In Thymus
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Waist circumference ( 26785701)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 EXT2 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1	8 interacting genes: CCR2 CCR4 F2RL1 FZD7 LINC00839 SLC22A1 SLC22A2 UNC93B1
Entrez ID		6582	1209
HPRD ID		04008	07544
Ensembl ID		ENSG00000112499	ENSG00000104853
Uniprot IDs		O15244	A0A0S2Z3H2 O96005
PDB IDs
Enriched GO Terms of Interacting Partners?
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