RECQL4 and PRSS23

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RECQL4	PRSS23
Description		RecQ like helicase 4	serine protease 23
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Oxidized Purine DNA Binding Annealing Helicase Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		RAPADILINO syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		7 interacting genes: ACD EP300 MCM10 POT1 PRSS23 TERF1 TERF2IP	26 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4
Entrez ID		9401	11098
HPRD ID		04805	07149
Ensembl ID		ENSG00000160957	ENSG00000150687
Uniprot IDs		O94761	O95084
PDB IDs		2KMU 5LST
Enriched GO Terms of Interacting Partners?
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