PRSS23 and SHMT1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRSS23	SHMT1
Description		serine protease 23	serine hydroxymethyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process	Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Metabolism of folate and pterines Carnitine synthesis
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562)
Interacting Genes		26 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4	11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3
Entrez ID		11098	6470
HPRD ID		07149	01643
Ensembl ID		ENSG00000150687	ENSG00000176974
Uniprot IDs		O95084	P34896
PDB IDs			1BJ4 6FL5
Enriched GO Terms of Interacting Partners?
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