PRSS23 and RECQL4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRSS23	RECQL4
Description		serine protease 23	RecQ like helicase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Oxidized Purine DNA Binding Annealing Helicase Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding
	Biological Process	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			RAPADILINO syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		26 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4	7 interacting genes: ACD EP300 MCM10 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		11098	9401
HPRD ID		07149	04805
Ensembl ID		ENSG00000150687	ENSG00000160957
Uniprot IDs		O95084	O94761
PDB IDs			2KMU 5LST
Enriched GO Terms of Interacting Partners?
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