PRSS23 and NIPBL

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRSS23	NIPBL
Description		serine protease 23	NIPBL cohesin loading factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytosol Integrator Complex SMC Loading Complex Intracellular Membrane-bounded Organelle Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Population Maintenance Positive Regulation Of Histone Deacetylation Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Transcriptional Activation By Promoter-enhancer Looping Cohesin Loading Positive Regulation Of Mitotic Cohesin Loading Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Cohesin Loading onto Chromatin
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Height ( 28552196 25282103 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		26 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4	7 interacting genes: CBX5 CDK6 DBN1 HINFP PRSS23 SP100 SUMO2
Entrez ID		11098	25836
HPRD ID		07149	10560
Ensembl ID		ENSG00000150687	ENSG00000164190
Uniprot IDs		O95084	A0A590UJS4 Q6KC79
PDB IDs			6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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