FOXP2 and CTBP1

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, two hybrid)

		FOXP2	CTBP1
Description		forkhead box P2	C-terminal binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Caudate Nucleus Development Putamen Development Cerebral Cortex Development Response To Testosterone Negative Regulation Of Transcription, DNA-templated Innate Vocalization Behavior	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation
Pathways			Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs			Formic acid
Diseases		Speech-language disorder 1 (SPCH1)
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 27798627) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Self-reported risk-taking behaviour ( 30271922 30181555) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)	Type 2 diabetes ( 31118516 32499647)
Interacting Genes		15 interacting genes: CCNC CDK3 CTBP1 CTBP2 FAM124A FOXP1 FOXP4 LNX1 MAPK3 PIN1 RPIA SDCBP SP4 TLE5 TSACC	92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		93986	1487
HPRD ID		05611	04015
Ensembl ID		ENSG00000128573	ENSG00000159692
Uniprot IDs		B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2	Q13363 X5D8Y5
PDB IDs		2A07 2AS5	1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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