HELB and POLA2

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		HELB	POLA2
Description		DNA helicase B	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus DNA Replication Factor A Complex Nucleolus Cytoplasm Site Of Double-strand Break	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding ATP Binding Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Repair Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 29403010 27863252)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		3 interacting genes: POLA1 POLA2 RPA1	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		92797	23649
HPRD ID		09979	10160
Ensembl ID		ENSG00000127311	ENSG00000014138
Uniprot IDs		Q8NG08	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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