POLA2 and ASCC2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	ASCC2
Description		DNA polymerase alpha 2, accessory subunit	activating signal cointegrator 1 complex subunit 2
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Nucleus Nucleoplasm Nuclear Speck Activating Signal Cointegrator 1 Complex
	Molecular Function	Molecular_function DNA Binding Protein Binding	Protein Binding Ubiquitin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	DNA Dealkylation Involved In DNA Repair Regulation Of Transcription, DNA-templated
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	ALKBH3 mediated reversal of alkylation damage
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		23649	84164
HPRD ID		10160	16515
Ensembl ID		ENSG00000014138	ENSG00000100325
Uniprot IDs		Q14181	A0A024R1E1 A0A024R1F9 Q9H1I8
PDB IDs		2KEB 4E2I 4Y97 5EXR	2DI0 6YXQ
Enriched GO Terms of Interacting Partners?
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