POLA2 and PRPF38A

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	PRPF38A
Description		DNA polymerase alpha 2, accessory subunit	pre-mRNA processing factor 38A
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Nucleus Nucleoplasm U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Molecular_function DNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	MRNA Splicing, Via Spliceosome
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	mRNA Splicing - Major Pathway
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	24 interacting genes: AP2M1 APP CHERP CLK1 CLK2 CSNK2A1 DHX8 DVL3 GTF3C1 JMJD6 MAPK6 POLA2 PPIG PRMT5 RBM39 RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRSF4 SRSF7 U2AF1 ZCCHC10
Entrez ID		23649	84950
HPRD ID		10160	10972
Ensembl ID		ENSG00000014138	ENSG00000134748
Uniprot IDs		Q14181	Q8NAV1
PDB IDs		2KEB 4E2I 4Y97 5EXR	4RZ9 4RZA 5F5S 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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