POLA2 and SNU13

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	SNU13
Description		DNA polymerase alpha 2, accessory subunit	small nuclear ribonucleoprotein 13
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Dense Fibrillar Component Nucleus Nucleoplasm U4atac SnRNP Nucleolus Box C/D RNP Complex Small-subunit Processome Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Molecular_function DNA Binding Protein Binding	RNA Binding Protein Binding SnoRNA Binding U4 SnRNA Binding U4atac SnRNA Binding U3 SnoRNA Binding Box C/D RNA Binding ATPase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	MRNA Splicing, Via Spliceosome Maturation Of LSU-rRNA RRNA Processing Maturation Of SSU-rRNA
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		Dacarbazine	(S)-3-phenyllactic acid Anisomycin
Diseases
GWAS		Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	16 interacting genes: CDKN2C CHST1 GTF3C1 HSPB2 LRIF1 MAP1LC3B NUFIP1 POLA2 PPIH RAD17 RBM10 RHOU SMN1 SMN2 SNW1 XRCC6
Entrez ID		23649	4809
HPRD ID		10160	03197
Ensembl ID		ENSG00000014138	ENSG00000100138
Uniprot IDs		Q14181	P55769 Q6FHM6
PDB IDs		2KEB 4E2I 4Y97 5EXR	1E7K 2JNB 2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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